Berberine Glucose Support

Berberine is a plant alkaloid found in barberry, goldenseal, and other plants that activates the enzyme AMPK, the same pathway activated by metformin. The blood sugar evidence is the most compelling: multiple RCTs show meaningful reductions in fasting glucose, HbA1c, and post-meal glucose spikes, with effect sizes comparable to metformin in some trials. Evidence for lipid lowering is also reasonable. What is often overlooked is the drug interaction profile: berberine is a CYP3A4 inhibitor and should be used cautiously with many medications, including cyclosporine and blood thinners. Standard dosing is 500mg two to three times daily with meals. Not a supplement to take casually if you are on prescription medications.

Also known as: Berberine HCl, Berberis aristata