Fish Oil

Omega-3 fatty acids (primarily EPA and DHA from fish oil) are among the most widely studied supplements. The evidence for triglyceride reduction is strong and consistent across multiple RCTs, high-dose omega-3 (2-4g daily EPA+DHA) reliably lowers high triglycerides. Cardiovascular outcomes are more mixed: early trials were promising, but larger meta-analyses show mixed results in general populations. The PISCES trial (2026) showed a striking 43% reduction in serious cardiovascular events in haemodialysis patients, confirming the mechanism works in high-risk populations. Omega-3 also supports anti-inflammatory pathways and shows reasonable evidence for mood support. Most people supplement at 1g daily, the effective doses in trials are typically 2-4g. Look for EPA/DHA content on the label, not total fish oil weight. A 1000mg fish oil capsule often contains only 300mg of actual omega-3.'s active ingredients, EPA and DHA, are the raw materials your body uses to build anti-inflammatory signaling molecules, maintain neuronal membrane fluidity, and regulate cardiovascular function through triglyceride reduction, platelet activity, and blood pressure. A Harvard meta-analysis of clinical trials found daily omega-3 supplementation is associated with an 8% reduced risk of heart attack and coronary heart disease death. The landmark PISCES trial, a multicenter RCT of 1,228 dialysis patients, found 4 grams per day reduced the composite risk of heart attack, stroke, cardiac death, and vascular amputation by 43% versus placebo. Brain health is a legitimate secondary target: DHA is a major structural component of the cerebral cortex, and observational data consistently links higher omega-3 intake to better cognitive outcomes and lower depression rates. People with high triglycerides, cardiovascular risk factors, low fish consumption, or mood concerns are the most logical users. High doses can increase bleeding time and may interact with anticoagulants; quality matters because poorly stored fish oil oxidizes readily. One of the supplements where the evidence is strong enough that the debate has shifted from whether to how much.

Also known as: Fish Oil, EPA/DHA, Omega-3 Fatty Acids